GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BLCA | cis | rs9457247 | 1 | rs376551 | chr6:167384923 | RNASET2 | chr6:167343008-167412795:- | -0.24 | -5.04 | 7.23E-7 | Crohn's disease |
| BLCA | cis | rs9457247 | 1 | rs376574 | chr6:167389956 | RNASET2 | chr6:167343008-167412795:- | -0.24 | -5.04 | 7.23E-7 | Crohn's disease |
| BLCA | cis | rs9815354 | 1 | rs3774372 | chr3:41877414 | ULK4 | chr3:41288091-42003660:- | 0.61 | 8.99 | 1.15E-17 | Diastolic blood pressure |
| BLCA | cis | rs9876781 | 1 | rs3774808 | chr3:48481647 | TREX1 | chr3:48501186-48509043:+ | -0.19 | -3.86 | 0.000134 | Longevity |
| BLCA | cis | rs9296504 | 1 | rs3778483 | chr6:46627100 | SLC25A27 | chr6:46620679-46645925:+ | -0.25 | -4.98 | 9.57E-7 | QRS complex (Sokolow-Lyon) |
| BLCA | cis | rs703842 | 1 | rs3782130 | chr12:58161898 | FAM119B | chr12:58166383-58176323:+ | 0.28 | 4.42 | 1.3E-5 | Multiple sclerosis |
| BLCA | cis | rs703842 | 1 | rs3782130 | chr12:58161898 | TSFM | chr12:58176536-58191367:+ | -0.39 | -6.92 | 1.87E-11 | Multiple sclerosis |
| BLCA | cis | rs703842 | 1 | rs3782130 | chr12:58161898 | XRCC6BP1 | chr12:58335445-58351051:+ | -0.24 | -4.09 | 5.28E-5 | Multiple sclerosis |
| BLCA | cis | rs2076028 | 1 | rs3788545 | chr22:39065172 | JOSD1 | chr22:39081549-39096459:- | -0.25 | -4.08 | 5.55E-5 | Resting heart rate |
| BLCA | cis | rs2149423 | 1 | rs3790012 | chr13:36773489 | SOHLH2 | chr13:36742347-36871992:- | 0.27 | 4.53 | 7.72E-6 | Glucose homeostasis traits |
| BLCA | cis | rs60843830 | 1 | rs3791220 | chr2:227066 | SH3YL1 | chr2:218138-264810:- | -0.44 | -11.57 | 9.11E-27 | Spherical equivalent (joint main effects and education interaction) |
| BLCA | cis | rs60843830 | 1 | rs3791221 | chr2:226933 | SH3YL1 | chr2:218138-264810:- | -0.44 | -11.45 | 2.67E-26 | Spherical equivalent (joint main effects and education interaction) |
| BLCA | cis | rs60843830 | 1 | rs3791223 | chr2:222336 | SH3YL1 | chr2:218138-264810:- | -0.45 | -11.82 | 1.11E-27 | Spherical equivalent (joint main effects and education interaction) |
| BLCA | cis | rs60843830 | 1 | rs3791224 | chr2:221981 | SH3YL1 | chr2:218138-264810:- | -0.45 | -11.79 | 1.37E-27 | Spherical equivalent (joint main effects and education interaction) |
| BLCA | cis | rs17030613 | 1 | rs3795819 | chr1:113234179 | ST7L | chr1:113066142-113162405:- | -0.43 | -6.46 | 3.26E-10 | Diastolic blood pressure;Blood pressure |